河北省心脑血管病防治协同创新中心
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河北省心脑血管病防治协同创新中心

河北省心脑血管病防治协同创新中心简介

Hebei Collaborative Innovation Center for Cardio-cerebral Vascular Disease

心脑血管病是造成国人死亡的第一原因,是危害人类健康的主要疾病。“河北省心脑血管病防治协同创新中心”(以下简称“中心”)的建立始于2012年3月15日由教育部和财政部实施的“高等学校创新能力提升计划”(即“2011计划”)。“中心”以降低心脑血管病发病率、提高人民健康水平为目的,以创新能力提升为突破,在基础科学研究之上,以协同创新、科研成果的快速临床转化为工作重点,积极开展“原创性、前瞻性和应用性”研究,努力为我省乃至国家的心脑血管病防治提供强有力的理论支撑,人才保障和智力支持。

“中心”由三个国家临床重点专科建设项目——发发棋牌神经内科、心血管内科和心脏大血管外科牵头,联合河北省神经病学重点实验室、河北省心脑血管病研究所、山东第一医科大学(原泰山医学院)动脉粥样硬化研究所、河北医科大学病理生理及生理教研室(河北省重点学科)、国家著名心脑血管病药物研发企业——石药集团、河北省疾病预防控制中心、同时联合省内11个设区市三级甲等医院的心脑血管病诊疗研究机构和相关临床科室,瞄准国际前沿,服务地方,凝练4大协同创新方向:①心脑血管病关键病例机制研究与临床治疗策略探讨;②创新心脑血管病治疗模式,提高治愈率、降低残疾率;③心脑血管病新药研发与有效药物筛选;④心脑血管病联合防控体系建设。打造国内一流、多学科合作、优势互补的综合平台,汇聚在国际学术界有重大影响力的著名专家学者为平台负责人,领导核心团队开展前沿性研究工作。

为了集中力量对血管疾病进行系统攻关研究,2015年1月25日,基于河北省心脑血管病防治协同创新中心、发发棋牌及山东第一医科大学动脉粥样硬化研究所而建立“河北省血管稳态重点实验室”,并于2018年6月8日通过河北省科学技术厅组织的“省级重点实验室”验收,已纳入省级重点实验室管理。实验室具备国际一流的神经血管分析和动态观测平台,配备高精尖仪器设备和顶级数据分析系统,并拥有临床病房作为基地,开展临床应用研究。

“中心”在建设中获得了国家自然科学基金,河北省教育厅、财政厅、卫健委(原卫计委)、科技厅,河北医科大学以及石药集团的大力支持。共建单位前期及成立后共荣获国家科技进步二等奖3项,国家技术发明二等奖1项,河北省科技进步一等奖8项,河北省科技进步二等奖11项,河北省科技进步三等奖35项,中国药学会科学技术三等奖1项。目前已发表学术论文2538篇,其中SCI论文324篇,其中8篇论文荣获国家卫计委脑防办百篇优秀论文。起草了《中国脑梗死中西医结合诊治指南2017》,参加撰写脑血管病指南6部,举办脑血管病新进展学习班4期,在全国专业学术会议大会交流20次。建成了河北省脑血管病分级诊疗区域中心-石家庄市17个县和24个社区医院双向转诊网络,是“河北省脑血管病规范化治疗培训基地”、“河北省疑难脑血管病远程会诊中心”,极大地促进了河北省脑血管病诊疗水平提升,团队获得了“河北省高校李保国式科技服务团队”。

“中心”本着优势互补、资源共享、互惠互利的原则,欢迎国内外医疗单位、专家学者积极参与“中心”的协同创新工作。

河北省心脑血管病防治协同创新中心的病房在17楼,医办室电话:0311-66636272,护理站电话:0311-66636271;重点实验室在18楼,联系电话:0311-66636287。

地址:发发棋牌北院区,中华北大街309号

附:近2年SCI论文汇总

1. Cui F, Guan Y, Guo J, et al. Chronic intermittent hypobaric hypoxia protects vascular endothelium by ameliorating autophagy in metabolic syndrome rats[J]. Life Sciences, 2018, 205:145-154.

2. Yang Y, Zhang X J, Zhang C, et al. Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice[J]. Neuroscience Letters, 2018, 678:48-54.

3. Chen Y, Jin S, Teng X, et al. Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress[J]. Oxidative Medicine & Cellular Longevity, 2018, 2018:6717212.

4. Yuan F, Wang H, Feng J, et al. Leptin Signaling in the Carotid Body Regulates a Hypoxic Ventilatory Response Through Altering TASK Channel Expression[J]. Frontiers in Physiology, 2018, 9:249.

5. Li G Q, Wang Z, Zhao T, et al. Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats[J]. Journal of Hypertension, 2018, 36(4):1.

6. Feng P, Zhang X, Li D, et al. Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease[J]. Neuropharmacology, 2018, 133:385-394.

7. Congrui M F, Na L, Yujia M Y, et al. Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension[J]. Canadian Journal of Physiology & Pharmacology, 2018, 96(8):807-814.

8. Chen Y, Zhang X, He J, et al. Delayed Administration of the Glucagon-Like Peptide 1 Analog Liraglutide Promoting Angiogenesis after Focal Cerebral Ischemia in Mice[J]. Journal of Stroke and Cerebrovascular Diseases, 2018, 27(5):1318-1325.

9. Qiu X, Liu K, Xiao L, Jin S, Dong J, Teng X, et al. Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level[J]. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018;1864(11):3723-3738.

10. Li L, Kang Y X, Ji X M, et al. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats[J]. CNS Neuroscience & Therapeutics, 2018, 24(2):115-125.

11. Hao W, Yang R, Yang Y, et al. Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress[J]. Life Sciences, 2018, 193:1-8.

12. Xiao L, Dong J H, Teng X, et al. Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling[J]. Journal of Hypertension, 2018, 36(3):651.

13. Jin S, Tan B, Teng X, et al. Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice[J]. Frontiers in Pharmacology, 2017, 8:682.

14. Jin S, Teng X, Xiao L, et al. Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway[J]. Experimental Biology & Medicine, 2017, 242(18):1831-1841.

15. Li H, Teng X, Yang R, et al. Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification[J]. Frontiers in Pharmacology, 2017, 8:629.

16. Jing Y, Li Z, Wang H, et al. Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats[J]. Stem Cells International,2017, 2017:5706193.

17. Jiao G, Zhang G, Wang H, et al. Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats[J]. Neural Plasticity, 2017, 2017(3):1-7.

18. Gao Y, Zhou JJ, Zhu Y, Wang L, Kosten TA, Zhang X, Li DP. Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress.Br J Pharmacol. 2017 Sep;174(17):2929-2940.

19. Chen R, Kong P, Zhang F, Shu YN, Nie X, Dong LH, Lin YL, Xie XL, Zhao LL, Zhang XJ, Han M. EZH2-mediated α-actin methylation needs lncRNA TUG1, and promotes the cortex cytoskeleton formation in VSMCs.Gene. 2017 Jun 15;616:52-57.

20. Fu C, Xue J, Wang R, Chen J, Ma L, Liu Y, Wang X, Guo F, Zhang Y, Zhang X, Wang S. Chemosensitive Phox2b-expressing neurons are crucial for hypercapnicventilatory response in the nucleus tractussolitarius.J Physiol. 2017 May 10.

21. Li X, Su L, Zhang X, Zhang C, Wang L, Li Y, Zhang Y, He T, Zhu X, Cui L. Ulinastatindownregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.Neurol Res. 2017 Apr;39(4):367-373.

22. He W, Cui L, Zhang C, Zhang X, He J, Xie Y, Chen Y. Sonic hedgehog promotes neurite outgrowth of cortical neurons under oxidative stress: Involving of mitochondria and energy metabolism.Exp Cell Res. 2017 Jan 1;350(1):83-90.

23. Tian H, Yao ST, Yang NN, Ren J, Jiao P, Zhang X, Li DX, Zhang GA, Xia ZF, Qin SC. D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway. Sci Rep. 2017 Aug 4;7(1):7333.)

24. Li Y, Zhang X, Cui L, Chen R, Zhang Y, Zhang C, Zhu X, He T, Shen Z, Dong L, Zhao J, Wen Y, Zheng X, Li P. Salvianolic Acids Enhance Cerebral Angiogenesis and Neurological Recovery by Activating JAK2/STAT3 Signaling Pathway after Ischemic Stroke in Mice. J Neuro chem. 2017 Oct;143(1):87-99.

25. Miao J, Wang L, Zhang X, Zhu C, Cui L, Ji H, Liu Y, Wang X. Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression. Neurochem Res. 2016 Sep;41(9):2300-10.

26. Ye Zhang a; Xiangjian Zhang; Lili Cui a; Rong Chen a; Cong Zhang a; Yaoru Li a; Tingting He a; Xingyuan Zhu a; Zuyuan Shen a; Lipeng Dong a; Jingru Zhao a; Ya Wen a; Xiufen Zheng a; Pan Li. Salvianolic Acids for Injection (SAFI) Promotes Functional Recovery and Neurogenesis via Sonic Hedgehog Pathway after Stroke in Mice. Neurochem Int. 2017 Nov;110:38-48.

27. Zhang L, Guo H, Yuan F, Hong ZC, Tian YM, Zhang XJ, Zhang Y. Limb remote ischemic per-conditioning protects heart against ischemia/reperfusion injury through opioid system in rats. Can J PhysiolPharmacol. 2017 Aug 1.

28. Li D, Liu C, Yang C, Wang D, Wu D, Qi Y, Su Q, Gao G, Xu Z, Guo Y. Slow intrathecal injection of rAAVrh10 enhances its transduction of spinal cord and therapeutic efficacy in a mutant SOD1 model of ALS. Neuroscience. 2017 Oct 9;365:192-205.

29. Zhang K, Yan J, Wang L, Tian X, Zhang T, Guo L, Li B, Wang W, Liu X. The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke. Neurosci Res. 2017 Sep 12. pii: S0168-0102(17)30464-9.

30. Jia LJ, Qu ZZ, Zhang XQ, Tian YJ, Wang Y. Uremic encephalopathy with isolated brainstem involvement revealed by magnetic resonance image: a case report. BMC Neurol. 2017 Aug 8;17(1):154.

31. Hu M, Liu Z, Lv P, Wang H, Zhu Y, Qi Q, Xu J, Gao L. Nimodipine activates neuroprotective signaling events and inactivates autophages in the VCID rat hippocampus. Neurol Res. 2017 Oct;39(10):904-909.

32. Zhang C, Zhao S, Zang Y, Gu F, Mao S, Feng S, Hu L, Zhang C. The efficacy and safety of Dl-3n-butylphthalide on progressive cerebral infarction: A randomized controlled STROBE study. Medicine (Baltimore). 2017 Jul;96(30):e7257.

33. Hou H, Miao J, Cao R, Han M, Sun Y, Liu X, Guo L. Rapamycin Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing the mTOR-STAT3 Pathway. Neurochem Res. 2017 May 30.

34. Sun C, Liu Y, Liu Y, Zhao M, Zhai J, Hao P, Wang Y, Ji Y. Characterization of aromatase expression in the spinal cord of an animal model of familial ALS. Brain Res Bull. 2017 Jun;132:180-189.

35. Dong RF, Zhang B, Tai LW, Liu HM, Shi FK, Liu NN. The Neuroprotective Role of MiR-124-3p in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5. J Cell Biochem. 2017 May 25. doi: 10.1002/jcb.26170.

36. Ji YX, Zhao M, Liu YL, Chen LS, Hao PL, Sun C. Expression of aromatase and estrogen receptors in lumbar motoneurons of mice. NeurosciLett. 2017 Jul 13;653:7-11.

37. Xue Y, Qu Z, Fu J, Zhen J, Wang W, Cai Y, Wang W. The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion. Brain Res Bull. 2017 May;131:221-228.

38. Wang L, Li B, Quan MY, Li L, Chen Y, Tan GJ, Zhang J, Liu XP, Guo L. Mechanism of oxidative stress p38MAPK-SGK1 signaling axis in experimental autoimmune encephalomyelitis (EAE). Oncotarget. 2017 Jun 27;8(26):42808-42816.

39. Yu P, Pan Y, Zheng H, Wang X, Yan H, Tong X, Jing J, Zhang X, Guo L, Wang Y. Association of high waist-to-height ratio with functional outcomes in patients with acute ischemic stroke: A report from the ACROSS-China study. Medicine (Baltimore). 2017 Mar;96(13):e6520.

40. Li Z, Duan W, Cui C, Liu Y, Li C, Liu Y. AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro. NeurosciLett. 2017 Feb 15;640:123-129.

41. Feng X, Hou H, Zou Y, Guo L. Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis. Bosn J Basic Med Sci. 2017 May 20;17(2):95-103.

42. Wang W, Duan W, Wang Y, Wen D, Liu Y, Li Z, Hu H, Cui H, Cui C, Lin H, Li C. Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice. Neurochem Res. 2017 Apr;42(4):986-996.

43. Zhu Y, Bai L, Liang P, Kang S, Gao H, Yang H. Disrupted brain connectivity networks in acute ischemic stroke patients. Brain Imaging Behav. 2017 Apr;11(2):444-453.

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